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Chasing C , C ‐Palladacycles
Author(s) -
GarcíaLópez JoséAntonio,
SauraLlamas Isabel
Publication year - 2021
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.202100414
Subject(s) - transmetalation , chemistry , oxidative addition , palladium , catalysis , reductive elimination , denticity , reagent , organometallic chemistry , ligand (biochemistry) , combinatorial chemistry , chelation , stereochemistry , organic chemistry , metal , biochemistry , receptor
The different approaches for the synthesis of C,C ‐palladacycles are reviewed in this manuscript. These species hold a bidentate ligand that chelates the Pd atom through two C ‐donor moieties. Their relevance is closely related to the fact that they are intermediates in many palladium‐catalyzed transformations. Furthermore, some of them have been used as efficient catalyst in cross coupling reactions. The review is structured according to the different strategies that have been employed to achieve the synthesis of the C,C ‐palladacycle derivatives, starting with those involving one elemental step (such as the oxidative addition of strained C−C bonds to Pd(0) or the transmetalation reactions between organometallic reagents and Pd(II) precursors), and continuing with more complex processes, where at least two elementary steps of Pd chemistry are involved (for example, carbometalation of alkenes followed by a C−H activation process). A final section highlights some aspects of synthetic methodologies based on Pd catalysis in which one or several C,C ‐palladacyclic intermediates are involved.