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Investigating the Bismuth Complexes with Benzoazacrown Tri‐ and Tetra‐Acetates
Author(s) -
Egorova Bayirta V.,
Matazova Ekaterina V.,
Aleshin Gleb Yu.,
Zubenko Anastasia D.,
Pashanova Anna V.,
Konopkina Ekaterina A.,
Mitrofanov Artem A.,
Smirnova Anastasia A.,
Trigub Alexander L.,
Karnoukhova Valentina A.,
Fedorova Olga A.,
Kalmykov Stepan N.
Publication year - 2021
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.202100256
Subject(s) - chemistry , potentiometric titration , aqueous solution , stability constants of complexes , chelation , extended x ray absorption fine structure , titration , tetra , crystallography , stereochemistry , benzimidazole , inorganic chemistry , medicinal chemistry , organic chemistry , absorption spectroscopy , physics , quantum mechanics , electrode
The complexation properties towards Bi 3+ of benzoazacrown ligands with five (H 3 BA3A) and six (H 4 BATA) heteroatoms and corresponding number of acetic arms have been investigated. Complexation constants were determined via potentiometric titration for BA3ABi complex (logβ=26.2) and refined for BATABi complex (logβ=31.7). According to NMR, X‐ray and EXAFS results, chelation of cation by H 3 BA3A appears to be outside the macrocyclic cavity both in the solid state and in the aqueous solution. This out‐cage location despite the high stability constant causes serum and in vivo instability of complex of smaller azacrown H 3 BA3A in contrast to H 4 BATA. Whereas the larger macrocycle and four pendant arms of H 4 BATA provide long‐range coordination effectively shielding the cation thereby ensuring high inertness in vitro , low accumulation of the radionuclide in the organs, and fast clearance.