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The Design of Gold Decorated Iron Borates (Fe 3 BO 6 and FeBO 3 ) for Photothermal Therapy and Boron Carriers
Author(s) -
Icten Okan
Publication year - 2021
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.202100217
Subject(s) - photothermal therapy , boron , nanoparticle , chemistry , colloidal gold , biocompatibility , nanotechnology , nuclear chemistry , irradiation , radiochemistry , materials science , organic chemistry , physics , nuclear physics
Cancer remains one of the serious diseases that threaten health, as treatment methods cannot meet the practical needs at the desired level. Therefore, developing new materials that can be used in cancer treatment is an essential effort. The purpose of this study was to develop new materials for boron neutron capture therapy (BNCT) as boron carriers and for photothermal therapy (PTT). Hence, iron borates were prepared with different morphologies and then coated with polydopamine (PDA) to increase the solubility and biocompatibility and also to contribute to the reduction in gold particles. Lastly, gold nanoparticles were deposited on the surface of iron borates, and the photothermal performance of the gold‐decorated and PDA‐coated iron borates (Fe 3 BO 6 @PDA−Au and FeBO 3 @PDA−Au) was investigated under 808 nm NIR laser. After 900 s irradiation, the temperatures of the dispersions of Fe 3 BO 6 @PDA−Au and FeBO 3 @PDA−Au nanoparticles reached 45.8 and 43.2 °C, respectively. Additionally, the approximate numbers of boron atoms per milligram of Fe 3 BO 6 @PDA−Au and FeBO 3 @PDA−Au nanoparticles were calculated to be 1.23×10 18 B mg −1 and 2.79×10 18 B mg −1 , respectively. In addition to PTT, the functional Fe 3 BO 6 @PDA−Au and FeBO 3 @PDA−Au nanoparticles introduced herein could be helpful in BNCT applications.