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Cover Feature: Formation of Cisplatin Adducts with the Epigenetically Relevant Nucleobase 5‐Methylcytosine (Eur. J. Inorg. Chem. 1/2021)
Author(s) -
Menke Annika,
Dubini Romeo C. A.,
Mayer Peter,
Rovó Petra,
Daumann Lena J.
Publication year - 2021
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.202001103
Subject(s) - chemistry , cisplatin , nucleobase , adduct , epigenetics , 5 methylcytosine , dna , electron paramagnetic resonance , cover (algebra) , nuclear magnetic resonance spectroscopy , dna methylation , stereochemistry , biochemistry , organic chemistry , genetics , nuclear magnetic resonance , gene , chemotherapy , mechanical engineering , engineering , biology , gene expression , physics
The Cover Feature shows the complexity of cisplatin‐nucleobase chemistry: With up to 4% abundance in the genome, 5‐methylcytosine ( 5mC ) is one of the most important epigenetic modifications. Change in DNA hypermethylation levels has even been linked to resistances to cisplatin treatment of cancer cells. A cisplatin‐5‐methylcytosine complex cis ‐[PtCl( 5mC )(NH 3 ) 2 ]Cl was identified out of a pool of complex mixtures. Using 1 H, 195 Pt, DOSY NMR spectroscopy, HR‐MS spectrometry, as well as EPR and UV‐Vis spectroscopy, multiple side products such as paramagnetic 5mC platinum blue compounds were also characterized. More information can be found in the Full Paper by L. Daumann and co‐workers.