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Protolysis of Amino Acid‐Functionalized Tin Sulfide Clusters
Author(s) -
Engel Annikka,
Dewald Hendrik,
Reuter Anna,
Klippstein Josefin,
Dehnen Stefanie
Publication year - 2020
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.202000290
Subject(s) - chemistry , tin , sulfide , amino acid , combinatorial chemistry , organic chemistry , cleavage (geology) , inorganic chemistry , biochemistry , geotechnical engineering , fracture (geology) , engineering
In order to gain information about the behavior of tin sulfide clusters with bio‐organic ligand shells under acidic conditions, such as found in undesirable cells for instance, we systematically treated amino acid‐functionalized tin sulfide clusters with different acids. For Boc‐protected amino acid derivatives, we could show that this treatment causes either cleavage of the protecting group of the amino acid or protolysis of the tin sulfide core under release of H 2 S and formation of the correspondingly functionalized organotin trichloride, depending on the nature of the acid. This points towards a potential future use of such species for targeted cytotoxic applications.