Premium
Development of an SBU‐Based Mechanochemical Approach for Drug‐Loaded MOFs
Author(s) -
Nawrocki Jan,
Prochowicz Daniel,
Wiśniewski Andrzej,
Justyniak Iwona,
Goś Piotr,
Lewiński Janusz
Publication year - 2020
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201901194
Subject(s) - chemistry , metal organic framework , mechanosynthesis , molecule , ibuprofen , nanotechnology , drug delivery , encapsulation (networking) , chemical engineering , drug , combinatorial chemistry , organic chemistry , adsorption , ball mill , materials science , psychology , psychiatry , medicine , computer network , computer science , engineering , pharmacology
Metal–organic frameworks (MOFs) have attracted a great deal of attention in the areas of biomedicine due to their versatile porous structures and are potentially ideal vehicles for loading bioactive molecules and controlling the release of small molecules. Current approaches for encapsulation of drug molecules in MOFs are usually based on multistep wet processes. We report here a novel simple and rapid solid‐state process that combines the mechanosynthesis of HKUST‐1 and the encapsulation of ibuprofen (IBU‐H), as a model drug molecule, in a one‐pot reaction involving a pre‐assembled [Cu 2 (IBU) 4 ] · 2DMF cluster. The ibuprofen‐loaded MOF composite (with 58.5 wt.‐% loading capacity) was also studied as a drug delivery carrier system in phosphate buffered saline (PBS) solution at 37 °C.