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Lanthanide(III) Based Complexes Containing 5,7‐Dimethyl‐1,2,4‐triazolo[1,5‐ a ]pyrimidine as Long‐Lived Photoluminescent Antiparasitic Agents
Author(s) -
EstebanParra Ginés M.,
Moscoso Inmaculada,
Cepeda Javier,
García Jose A.,
SánchezMoreno Manuel,
RodríguezDiéguez Antonio,
Quirós Miguel
Publication year - 2020
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201901119
Subject(s) - chemistry , lanthanide , pyrimidine , photoluminescence , antiparasitic , ligand (biochemistry) , antiparasitic agent , luminescence , derivative (finance) , combinatorial chemistry , stereochemistry , antenna effect , organic chemistry , biochemistry , receptor , medicine , ion , physics , optoelectronics , pathology , financial economics , optics , economics , veterinary medicine
We report the synthesis and characterization of a new family of lanthanide‐based compounds containing a triazolopyrimidine derivative ligand, having the [Ln(H 2 O) 9 ][Ln(NO 3 ) 6 ] · 9dmtp {Ln = La ( 1 ) and Nd ( 2 )} and [Ln(H 2 O) 3 (NO 3 ) 3 ] · 3dmtp {Ln = Eu ( 3 ), Gd ( 4 ), Tb ( 5 ), Dy ( 6 ), Er ( 7 ) and Yb ( 8 ), where dmtp = dimethyl‐1,2,4‐triazolo[1,5‐ a ]pyrimidine} formulae. These materials possess variable structures and show variable luminescence properties, as well as interesting antiparasitic activities against pathogenic agent of Leishmaniasis and Chagas disease, which makes these compounds excellent candidates to be further investigated to develop new drugs against those neglected diseases. Moreover, the measurement of the photoluminescence properties of Eu‐ and Tb‐counterparts revealed that the dmtp ligand possesses accessible triplet states which can not only promote an efficient antenna effect that enhances lanthanide‐based emissions but also prolong them to several milliseconds.