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Expanding the Scope of Water‐Stable Rhenium(V)‐NHC Complexes – Synthesis, Characterization, and Derivatization
Author(s) -
Bornemann Dustin,
Schlemper Lukas,
Trapp Nils,
Togni Antonio
Publication year - 2020
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201901077
Subject(s) - chemistry , rhenium , deprotonation , ligand (biochemistry) , aqueous solution , hydride , bromide , medicinal chemistry , coordination complex , combinatorial chemistry , inorganic chemistry , organic chemistry , ion , metal , receptor , biochemistry
The synthesis of novel Re V –NHC oxo complexes bearing a tridentate scorpionate NHC ligand is reported. The complexes are accessible in a two‐step procedure from the precursor (N n Bu 4 )[ReOCl 4 ] by in situ deprotonation of the imidazolium salt 2,2‐bis(3‐methyl‐1 H ‐imidazol‐3‐ium‐1‐yl)acetate bromide ( L1 ‐H 2 ) using sodium hydride. The obtained complex [ReO(glyc) L1 ] (glyc = ethylene glycolato) is readily converted into [ReOCl 2 ( L1 )] which serves as starting material for the synthesis of water stable [ReO( L1 )X] derivatives (X = dianionic ligand). In one case the formation of a Re dioxo species K 2 [ReO 2 (CN) 2 ( L1 )] was observed in aqueous conditions. All complexes were isolated, fully characterized and analyzed by XRD studies, demonstrating for the first time a coordination of scorpionate ligand L1 to rhenium. Additionally, their short‐ and long‐term stability in various aqueous media is an asset in view of developing new rhenium‐based metallodrugs.