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Amino Acid Functionalized Organotin Trichlorides and Their Tin Sulfide Clusters
Author(s) -
Engel Annikka,
Dehnen Stefanie
Publication year - 2019
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201900528
Subject(s) - chemistry , valine , tin , amino acid , alanine , sulfide , stereochemistry , serine , phenylalanine , medicinal chemistry , nuclear magnetic resonance spectroscopy , organic chemistry , biochemistry , enzyme
We present a new synthesis of functionalized tin sulfide clusters via organotin trichlorides with boc‐protected amino acids (R AAc SnCl 3 ). In this work we used non‐polar (alanine, valine, leucine, phenylalanine and methionine), polar/neutral (serine and tyrosine) and basic (histidine) amino acids. We obtained single crystals from a Boc‐protected valine derivative of the originally used organotin trichloride R 1 SnCl 3 [R 1 = CMe 2 CH 2 C(O)Me] and determined its structure by means of X‐ray diffraction. A subsequent reaction with sulfide sources led to a variety of respective cluster structures. By using either (Me 3 Si) 2 S or Na 2 S, the reaction product turns out to be the defect‐heterocubane cluster [(R AAc Sn) 3 S 4 Cl] or the “doppeldecker”‐type cluster [(R AAc Sn) 4 S 6 ], respectively, according to 119 Sn NMR spectroscopy.