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Bimodal Probe for Magnetic Resonance Imaging and Photoacoustic Imaging Based on a PCTA‐Derived Gadolinium(III) Complex and ZW800–1
Author(s) -
Devreux Marie,
Henoumont Céline,
Dioury Fabienne,
Stanicki Dimitri,
Boutry Sébastien,
Larbanoix Lionel,
Ferroud Clotilde,
Muller Robert N.,
Laurent Sophie
Publication year - 2019
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201900387
Subject(s) - gadolinium , magnetic resonance imaging , photoacoustic imaging in biomedicine , nuclear magnetic resonance , materials science , molecular imaging , fluorophore , resolution (logic) , chemistry , optics , fluorescence , in vivo , radiology , medicine , physics , computer science , microbiology and biotechnology , artificial intelligence , biology , metallurgy
One of the most widely used techniques to obtain anatomical information is magnetic resonance imaging (MRI). Despite its high resolution, it has a low sensitivity which could be enhanced by coupling MRI with a more sensitive technique such as photoacoustic imaging (PAI). The development of a bimodal agent could thus lead to hybrid images with a high anatomical resolution provided by MRI and a precise localization of the contrast agent thanks to PAI. The probes used in this work are a gadolinium(III) complex derived from PCTA‐[12] for MRI and the ZW800–1 fluorophore for PAI. These two organic parts have been attached to a L ‐lysine derivative which has a third site for potential conjugation to a biovector, thus opening the field of targeted probes for molecular imaging. Preliminary relaxometric and photoacoustic characterizations indicate that this bimodal agent is a promising compound for bimodal imaging.