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Employing Linear Tridentate Ligands with Pyrazole End Groups in Catalytic Tyrosinase Model Chemistry: Does Hemilability Matter?
Author(s) -
Herzigkeit Benjamin,
Jurgeleit Ramona,
Flöser Benedikt M.,
Meißner Nadja E.,
Engesser Tobias A.,
Näther Christian,
Tuczek Felix
Publication year - 2019
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201900242
Subject(s) - chemistry , copper , amine gas treating , pyrazole , perchlorate , catalysis , tyrosinase , medicinal chemistry , polymer chemistry , combinatorial chemistry , stereochemistry , organic chemistry , ion , enzyme
Several copper(I) and copper(II) complexes supported by hemilabile bis(pyrazolylmethyl)amine ( pzma ) ligands are synthesized and structurally characterized. The copper(I) complexes with hexafluoridophosphate or perchlorate anions are employed as catalysts for the tyrosinase‐like oxygenation of 2,4‐di‐ tert ‐butylphenol (DTBP‐H). Their activities are comparable to that of [Cu(MeCN) 2 PMP ]PF 6 ( PMP = pyrazolylmethylpyridine) investigated earlier. In contrast to the copper(I) pzma complexes, their congeners supported by non‐hemilabile bis(pyrazolylethyl)amine ( pzea ) ligands are found to be catalytically inactive.