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A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis ‐[Pt(PPh 3 ) 2 (L 1 ‐ O,S )]PF 6 (L 1 ‐ O,S = N , N ‐Morpholine‐ N′ ‐benzoylthiourea)
Author(s) -
Pérez Hiram,
Ramos Raúl,
Plutín Ana M.,
Mocelo Raúl,
Erben Mauricio F.,
Castellano Eduardo E.,
Batista Alzir A.
Publication year - 2019
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201900042
Subject(s) - chemistry , steric effects , platinum , crystallography , intramolecular force , ligand (biochemistry) , crystal structure , stacking , palladium , hydrogen bond , stereochemistry , molar conductivity , molecule , metal , biochemistry , receptor , organic chemistry , catalysis
A novel mixed platinum(II) complex with general formula [Pt(PPh 3 ) 2 (L 1 ‐ O,S )]PF 6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR ( 1 H, 13 C and 31 P) spectroscopic methods. The crystal structure has been determined by single‐crystal X‐ray crystallography. The molecule presents an almost ideal square‐planar geometry, and the crystal is stabilized by weak C–H ··· O and C–H ··· F hydrogen bonds, and C–H ··· π stacking interactions. The steric congestion of ligands is described by “exact” cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X‐ray structure revealed the proximity of the ortho phenyl proton of one PPh 3 ligand to platinum(II) showing rare intramolecular C–H ··· Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis .