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Chiral‐at‐Ruthenium Catalyst with Sterically Demanding Furo[3,2‐ b ]pyridine Ligands
Author(s) -
Cui Tianjiao,
Qin Jie,
Harms Klaus,
Meggers Eric
Publication year - 2019
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201801362
Subject(s) - ruthenium , chemistry , steric effects , enantioselective synthesis , catalysis , pyridine , stereocenter , carbene , combinatorial chemistry , denticity , stereochemistry , medicinal chemistry , metal , organic chemistry
A sterically demanding derivative of a previously introduced chiral‐at‐metal ruthenium(II) catalyst scaffold is introduced. It is composed of two bidentate furo[3,2‐ b ]pyridyl functionalized N‐heterocyclic carbene ligands. Their cis ‐coordination generates helical chirality and a stereogenic ruthenium center. Two additional labile acetonitriles compose the catalytic site which is highly shielded by two 2‐( tert ‐butyl)furo[3,2‐ b ]pyridine moieties. The synthesis of the non‐racemic ruthenium catalyst and its catalytic properties for the enantioselective alkynylation of 2,2,2‐trifluoroacetophenone and pentafluorobenzaldehyde are reported and compared with sterically less demanding derivatives.