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Cover Feature: One Step Up in Antiproliferative Activity: The Ru‐Zn Complex [RuCp(PPh 3 ) 2 ‐µ‐dmoPTA‐1κ P :2κ 2 N , N′ ‐ZnCl 2 ](CF 3 SO 3 ) (Eur. J. Inorg. Chem. 43/2018)
Author(s) -
Mendoza Zenaida,
LorenzoLuis Pablo,
Scalambra Franco,
Padrón José M.,
Romerosa Antonio
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201801353
Subject(s) - chemistry , ruthenium , bimetallic strip , moiety , molecule , stereochemistry , ligand (biochemistry) , crystallography , metal , organic chemistry , biochemistry , receptor , catalysis
The Cover Feature shows the complex [RuCp(PPh 3 ) 2 ‐μ‐dmoPTA‐1κP:2κ 2 N,N'‐ZnCl 2 ] approaching a DNA molecule. This Ru‐Zn bimetallic complex consists of one [RuCp(PPh 3 ) 2 ] + unit coordinated to the P atom of the ligand 3,7‐dimethyl‐1,3,7‐triaza‐5‐phosphabicyclo[3.3.1]nonane (dmoPTA), which also coordinates a {ZnCl 2 } moiety by its NCH 3 atoms. This complex displays one of the highest known antiproliferative activities against human lung, cervix, breast, and colon solid tumor cell lines (GI 50 = 30–83 nm), while is 3–8 times less active against non‐tumor human cell line BJ‐hTert. More information can be found in the Full Paper by A. Romerosa et al.