Premium
Multifunctional Mesoporous ZnO@BMMs with Strong Fluorescence and High Loading Capacity for Controlled Drug Delivery
Author(s) -
Li Junfang,
Sun Jihong,
Bai Shiyang,
Wu Xia,
Xue Rensheng
Publication year - 2019
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201801231
Subject(s) - chemistry , fluorescence , mesoporous material , x ray photoelectron spectroscopy , doping , zinc , drug delivery , luminescence , chemical engineering , nuclear chemistry , mesoporous silica , vacancy defect , materials science , organic chemistry , catalysis , crystallography , optics , physics , engineering , optoelectronics
Multifunctional mesoporous ZnO@BMMs were prepared via a facile and reliable post treatment, in which the influence of various parameters, including the amount of ZnCl 2 doping, the different anions of the zinc salt, and the roasting temperature, on their structure, properties, and fluorescence performance were investigated by XRD, SEM, TEM, EDS, DLS, XPS, BET, PL, UV, and TGA/DTG. The drug loading and release performance was explored by using ibuprofen (IBU) as a model drug. The results showed that the ZnO@BMMs before drug‐loading and after drug release possessed not only ordered mesoporous structures, but also excellent luminescence, while the specific surface area decreased as the amount of Zn‐doping increased. The fluorescence profiles exhibited near band edge emission at 392 nm and defect of oxygen vacancy emission centered at 436 nm and 510 nm. The drug delivery behavior featured a high loading capacity (up to 250 mg/g) and good sustained release performance accompanied with strong fluorescence.