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Green‐Light‐Induced PhotoCORM: Lysozyme Binding Affinity towards Mn I and Re I Carbonyl Complexes and Biological Activity Evaluation
Author(s) -
Mansour Ahmed M.
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201801055
Subject(s) - chemistry , cycloaddition , reactivity (psychology) , medicinal chemistry , deprotonation , ligand (biochemistry) , azide , bromide , stereochemistry , lysozyme , alkyne , catalysis , inorganic chemistry , organic chemistry , ion , medicine , biochemistry , alternative medicine , receptor , pathology
Reaction of N ‐(2‐pyridylmethylene)benzene‐1,4‐diamine (L) with [MBr(CO) 5 ] (M = Mn I and Re I ) affords complexes of the type [MBr(CO) 3 L] [M = Mn I ( 1 ) and Re I ( 2 )]. Complex 1 releases CO upon illumination with light in the range of 525–468 nm. No photo induced CO release is detected from 2 . Reactive azide complex 3 , obtained by bromide's ligand exchange, reacts with the electron‐poor alkyne dimethyl acetylene dicarboxylate giving triazolato complex 4 ([Mn(triazolate COOMe,COOMe )(CO) 3 L]) via the free catalyst [3+2] cycloaddition coupling. Complex 1 exhibits interesting antifungal activity (MIC = 30 nM) against Candida albicans and Cryptococcus neoformans as well as cytotoxic activity of 12.56 µg/mL against noncancerous human embryonic kidney cells. Reactivity of the complexes towards hen egg white lysozyme is studied by electrospray ionization mass spectrometry.