Premium
Catalytic Cleavage of the Amide Bond in Urea Using a Cobalt(III) Amino‐Based Complex
Author(s) -
Uprety Bhawna,
Arderne Charmaine,
Bernal Ivan
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201800975
Subject(s) - chemistry , amine gas treating , amide , urea , catalysis , bond cleavage , cleavage (geology) , kinetics , ammonia , medicinal chemistry , cobalt , inorganic chemistry , tris , polymer chemistry , organic chemistry , biochemistry , physics , geotechnical engineering , quantum mechanics , fracture (geology) , engineering
The urease mimetic activity of Co III amine complexes with respect to cleavage of urea was explored using SCXRD and spectroscopic techniques. The reaction of [Co III (tren)Cl 2 ]Cl [tren = tris(2‐aminoethyl)amine] with urea results in the formation of an isocyanato complex {[Co III (tren)(NH 3 )(NCO)]Cl 2 } and ammonia, following the cleavage of the amide bond. The reaction progress and the subsequent formation of cleavage products were confirmed by SCXRD analysis of the reactants as well as the products obtained during the reaction. The reaction was found to be pH and temperature dependent, and the reaction conditions were optimized to maximize conversion. The reaction kinetics was followed spectroscopically ( 1 H NMR and UV/Vis), following the decrease in urea concentration or the increase in pH succeeding ammonia formation. A detailed kinetic study revealed an overall second order rate law and k obs was found to be 3.89 × 10 –4 m –1 s –1 .