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Tracking Fluorescent Polyoxometalates within Cells
Author(s) -
Modugno Gloria,
Fabbretti Elsa,
Dalle Vedove Andrea,
Da Ros Tatiana,
Maccato Chiara,
Hosseini Hadigheh Sadat,
Bonchio Marcella,
Carraro Mauro
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201800802
Subject(s) - internalization , chemistry , fluorescence , amphiphile , cytoplasm , confocal microscopy , membrane , confocal , covalent bond , biophysics , nanotechnology , fluorescence microscope , cell , hek 293 cells , cell membrane , förster resonance energy transfer , microbiology and biotechnology , biochemistry , copolymer , polymer , organic chemistry , physics , materials science , quantum mechanics , geometry , mathematics , biology , gene
Novel organic‐inorganic polyoxometalates (POMs) decorated with covalent fluorescent tags have been designed for cell internalization. Their localization within model HEK cells is readily accomplished by confocal fluorescence microscopy. While cell internalization is dictated by the formation of the amphiphilic POM‐based nanostructures, their cytoplasmic‐nuclear trafficking appears to be regulated by a subtle interplay of the organic‐inorganic domains of the nanoassemblies which, in turn, impacts their dynamic behavior and capability to interact with cell membranes.