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Straightforward Synthesis of L‐PEI‐Coated Gold Nanoparticles and Their Biological Evaluation
Author(s) -
Bouché Mathilde,
Fournel Sylvie,
Kichler Antoine,
Selvam Tamilselvi,
Gallani JeanLouis,
BelleminLaponnaz Stéphane
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201800489
Subject(s) - biocompatible material , chemistry , colloidal gold , nanoparticle , nanotechnology , gene delivery , combinatorial chemistry , transfection , materials science , biomedical engineering , biochemistry , medicine , gene
Functionalized gold nanoparticles receive much attention for biomedical applications thanks to their improved in vivo circulation time and colloidal stability. This work aimed at developing a simple and efficient synthetic route for synthesizing nanoparticles coated with linear polyethyleneimine for use as non‐toxic platforms in non‐viral gene delivery. We show that the reproducible one‐pot synthesis of gold nanoparticles stabilized with a biocompatible linear PEI yields nanodelivery devices offering a low toxicity and very good transfection efficiency.