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Half‐Sandwich Metal Complexes with β‐Diketone‐Like Ligands and Their Anticancer Activity
Author(s) -
Pettinari Riccardo,
Marchetti Fabio,
Di Nicola Corrado,
Pettinari Claudio
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201800400
Subject(s) - chemistry , prodrug , metal , diketone , stereochemistry , in vitro , combinatorial chemistry , anticancer drug , medicinal chemistry , organic chemistry , biochemistry , pharmacology , drug , medicine
Half‐sandwich organometal complexes of Ru II , Os II , Rh III and Ir III with β‐diketone‐like ligands have been extensively explored as potential prodrugs in anticancer therapy in recent years. Here a minireview of this class of compounds is provided. A discussion of the basic structural features of the metal complexes is given, together with their in vitro anticancer activity.