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Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis‐1,8‐naphthalimide Ligands
Author(s) -
Streciwilk Wojciech,
Terenzi Alessio,
Lo Nardo Federico,
Prochnow Pascal,
Bandow Julia Elisabeth,
Keppler Bernhard K.,
Ott Ingo
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201800384
Subject(s) - chemistry , moiety , intercalation (chemistry) , dna , ligand (biochemistry) , stereochemistry , carbene , rhodium , group 2 organometallic chemistry , combinatorial chemistry , metal , organometallic chemistry , molecule , organic chemistry , biochemistry , receptor , catalysis
Organometallic N‐heterocyclic carbene (NHC) complexes with intercalating bis‐naphthalimide ligands were prepared and evaluated biologically. Cytotoxic effects against tumor cells or bacteria were strongly ligand dependent with minor influence of the metal (Ag, Ru, Rh, Au) centers. Complex 8b with a rhodium(I) NHC moiety was studied in more detail for its DNA interacting properties in comparison to the metal free ligand. These studies showed a good DNA binding pattern with some preference for the telomeric quadruplex structure h Telo. Complex 8b was also shown to trigger additional coordinative binding to the DNA and therefore represents an useful tool compound with a mixed intercalative/coordinative DNA binding mode.