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Nonionic Surfactants as Potential Carriers of a Synthesized Pyrimidine Derivative: Spectroscopic and Quantum Chemical Investigations
Author(s) -
Ghosh Swadesh,
Singharoy Dipti,
Dhara Anamika,
Naskar Jnan Prakash,
Bhattacharya Subhash Chandra
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201800207
Subject(s) - chemistry , pyrimidine , cationic polymerization , aqueous solution , zeta potential , solubility , derivative (finance) , density functional theory , bioavailability , combinatorial chemistry , organic chemistry , computational chemistry , chemical engineering , nanoparticle , stereochemistry , financial economics , economics , bioinformatics , engineering , biology
Currently, a major problem is the poor water solubility and bioavailability of many pharmaceuticals. Using different types of surfactants is an effective strategy to overcome this problem. Herein a pyrimidine‐based Schiff base, 2‐[2‐(anthracen‐9‐ylmethylene) hydrazinyl]‐4,6‐dimethyl pyrimidine (ANHP), has been synthesized and characterized by different spectroscopic methods. A comparative study of drug carrier properties of cationic, anionic, and the nonionic surfactants with this pyrimidine derivative (ANHP) in aqueous solution is the key research interest of this work. From fluorescence studies, the interaction of ANHP with the different types of surfactants were compared and binding constants of ANHP in vesicles were determined. The drug carrier properties of different surfactants were investigated by using different spectroscopic techniques. DLS, zeta potential, and AFM studies have shown that in the presence of ANHP, nonionic surfactants take a vesicular shape. Several experimental results clearly indicate that Ig‐720 is the better choice as ANHP carrier among all the surfactants investigated. In addition, the structure of ANHP has been optimized by density functional theory (DFT). The theoretical and experimental results have been compared.