Premium
A Systematic Synthetic Study of the Aqueous Chemistry of Binary Boron–Hydroxycarboxylic Acid Systems: Boron Structural Speciation Correlation to the Biotoxicity Profile
Author(s) -
Matsia Sevasti,
Tsave Olga,
Hatzidimitriou Antonios,
Gabriel Catherine,
Bertmer Marko,
Salifoglou Athanasios
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201701212
Subject(s) - chemistry , boron , reactivity (psychology) , aqueous solution , citric acid , ternary operation , nuclear magnetic resonance spectroscopy , molecule , medicinal chemistry , crystallography , nuclear chemistry , stereochemistry , organic chemistry , medicine , alternative medicine , pathology , computer science , programming language
In an attempt to delve into the chemistry of boron, whose role in biology still remains unclear, yet its presence and influence is undisputed, research was launched into the structural speciation of B III with physiological binders. The latter molecules involve hydroxycarboxylic glycolic, 2‐hydroxy‐isobutyric, and citric acids. Their pH‐specific reactivity is systematically investigated synthetically in binary and ternary systems of B III , leading to well‐defined crystalline materials, [B(OCH 2 COO) 2 ](CH 6 N 3 ) ( 1 ), Na[B{OC(CH 3 ) 2 COO} 2 ] ( 2 ), [B(C 6 H 6 O 7 ) 2 ](CH 6 N 3 ) ( 3 ), [B(C 6 H 6 O 7 ) 2 ](C 3 H 5 N 2 ) ( 4 ), {Na 4 [B(C 6 H 5 O 7 )(C 6 H 4 O 7 )]} n · 2 n H 2 O ( 5 ), and K[B(C 6 H 6 O 7 ) 2 ] · 2H 2 O ( 6 ). Complexes 1 – 6 are characterized physicochemically through: elemental analysis; FTIR spectroscopy; 1 H NMR, 13 C NMR, and solution 11 B NMR spectroscopy; TGA; luminescence; and X‐ray crystallography. The collective data project retention of B III tetrahedrality, with the stability of the arising complex supported by five‐membered boracyclic rings. The structurally differentiated organic ligands serve as the basis of further biological evaluation of the emerging materials in 3T3‐L1, C2C12, A549, and Saos‐2 cultures. The effect on cell survival, morphology, and migration of 1 , 2 , and 5 is investigated in a time‐, dose‐, tissue‐, and structure‐specific manner. The results portray a well‐defined biotoxic profile for soluble bioavailable binary B III –hydroxycarboxylato species, further justifying perusal of boron's structure‐specific reactivity profile in cellular physiology.