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Synthesis, Structural Characterization and Anti‐Proliferative Activity of (κ 1 ‐ C )‐ and (κ 2 ‐ C , S )‐Pt II Complexes Bearing Thioether‐Functionalized N‐Heterocyclic Carbenes
Author(s) -
Egly Julien,
Bouché Mathilde,
Chen Weighang,
MaisseFrançois Aline,
Achard Thierry,
BelleminLaponnaz Stéphane
Publication year - 2018
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201701183
Subject(s) - thioether , chemistry , platinum , moiety , ligand (biochemistry) , reactivity (psychology) , carbene , stereochemistry , pyridine , nuclear magnetic resonance spectroscopy , medicinal chemistry , organic chemistry , medicine , biochemistry , receptor , pathology , catalysis , alternative medicine
A series of platinum(II) complexes bearing thioether‐functionalized N‐heterocyclic carbene ligands have been synthesized and characterized. The hemilabile and reversible character (i.e., coordination/decoordination) of the sulfur moiety in these platinum complexes has been established by ligand displacement (addition of pyridine) and ligand abstraction (on silica gel). The chemical reactivity of these complexes with glutathione has been investigated by NMR spectroscopy and mass spectrometry. Their biological activity towards various human cancer cells has been studied; these S ‐functionalized NHC–platinum complexes displayed moderate cytotoxicity.