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A pH‐Sensitive Composite with Controlled Multistage Drug Release for Synergetic Photothermal Therapy and Chemotherapy
Author(s) -
Yang Zheng,
Xu Wanghua,
Ji Mingxiang,
Xie Anjian,
Shen Yuhua,
Zhu Manzhou
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201701081
Subject(s) - nanocomposite , photothermal therapy , chemistry , drug delivery , composite number , controlled release , nanotechnology , drug , cancer therapy , nuclear chemistry , chemical engineering , cancer , materials science , pharmacology , composite material , organic chemistry , medicine , engineering
Multifunctional core–shell nanocomposites are excellent platforms for effective drug delivery, and controlled release is attracting increasing attention from researchers owing to its advantages in cancer therapy. Here, a new nanocomposite containing nitrogen‐doped carbon dots (N‐CDs) embedded in ferromagnetic Fe 3 O 4 cores and a pH‐sensitive shell constituted by hydroxyapatite (HA) with loaded 5‐fluorouracil (5‐FU) was successfully synthesized. The nanocomposite can be used for near‐infrared laser‐induced photothermal cancer therapy and synergetic chemotherapy. The pH‐sensitive HA shell exhibits a high drug‐loading capability and achieves a pH‐controlled and multistage drug release. As a result, this multifunctional core–shell N‐CDs@Fe3O4@HA‐5FU nanocomposite is an excellent and promising candidate with significant potential for targeted and synergetic cancer treatment.