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Electrochemical Investigation of the Eu 3+/2+ Redox Couple in Complexes with Variable Numbers of Glycinamide and Acetate Pendant Arms
Author(s) -
Burnett Marianne E.,
Adebesin Bukola,
Funk Alexander M.,
Kovacs Zoltan,
Sherry A. Dean,
Ekanger Levi A.,
Allen Matthew J.,
Green Kayla N.,
Ratnakar S. James
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201701070
Subject(s) - chemistry , electrochemistry , redox , inorganic chemistry , electrode
The Eu 3+/2+ redox couple provides a convenient design platform for responsive p O 2 sensors for magnetic resonance imaging (MRI). Specifically, the Eu 2+ ion provides T 1w contrast enhancement under hypoxic conditions in tissues, whereas, under normoxia, the Eu 3+ ion can produce contrast from chemical exchange saturation transfer in MRI. The oxidative stability of the Eu 3+/2+ redox couple for a series of tetraaza macrocyclic complexes was investigated in this work using cyclic voltammetry. A series of Eu‐containing cyclen‐based macrocyclic complexes revealed positive shifts in the Eu 3+/2+ redox potentials with each replacement of a carboxylate coordinating arm of the ligand scaffold with glycinamide pendant arms. The data obtained reveal that the complex containing four glycinamide coordinating pendant arms has the highest oxidative stability of the series investigated.