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Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium
Author(s) -
Hashami Zohreh,
Martins Andre F.,
Funk Alexander M.,
Jordan Veronica Clavijo,
Petoud Stéphane,
Eliseeva Svetlana V.,
Kovacs Zoltan
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201701003
Subject(s) - tropone , chemistry , lanthanide , moiety , ligand (biochemistry) , aqueous solution , aqueous medium , porphyrin , ion , photochemistry , stereochemistry , organic chemistry , biochemistry , receptor
In this work, we describe a novel DOTA (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (ligand 1 ). Ln 3+ complexes of 1 have one inner‐sphere water molecule. The r 1 relaxivity of Gd 1 is similar to that of the commercial Gd‐based MRI agents. The neutral O ‐donor atom of the tropone moiety slows down the water exchange by a factor of 3 compared to that for GdDOTA. In addition, complexes Nd 1 and Yb 1 exhibit significant NIR emission in aqueous solutions, which indicates that the tropone unit is an efficient sensitizer for these Ln 3+ ions. Therefore, this new ligand is a promising platform for the design of Ln 3+ ‐based dual MR/optical imaging probes.