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Sugar‐Incorporated N‐Heterocyclic‐Carbene‐Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
Author(s) -
Cucciolito Maria E.,
Trinchillo Marina,
Iannitti Roberta,
Palumbo Rosanna,
Tesauro Diego,
Tuzi Angela,
Ruffo Francesco,
D'Amora Angela
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201700768
Subject(s) - chemistry , carbene , cationic polymerization , ligand (biochemistry) , sugar , combinatorial chemistry , cancer cell lines , cytotoxicity , cisplatin , stereochemistry , organic chemistry , in vitro , cancer cell , biochemistry , cancer , receptor , medicine , surgery , chemotherapy , catalysis
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside‐incorporated N‐heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC‐3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes.