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Solid‐State Structure of a Bromo(difluoromethylenephosphonato)cuprate – a Key Intermediate for the Synthesis of α,α‐Difluoromethylenephosphonates
Author(s) -
Alter Christian,
Neumann Beate,
Stammler HansGeorg,
Weber Lothar,
Hoge Berthold
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201700526
Subject(s) - chemistry , cuprate , reagent , halide , reactivity (psychology) , molecule , copper , zinc , single crystal , crystal structure , combinatorial chemistry , characterization (materials science) , organic synthesis , solid state , crystallography , inorganic chemistry , catalysis , organic chemistry , nanotechnology , superconductivity , medicine , physics , alternative medicine , materials science , pathology , quantum mechanics
Many approaches to introduce the CF 2 P(O)(OR) 2 unit into organic molecules make use of Cu I ‐catalyzed couplings between organic halides and BrZnCF 2 P(O)(OR) 2 . Despite the great importance of this process for the synthesis of α,α‐difluoromethylenephosphonates, the constitution and molecular structures of the organozinc precursor and the catalytically relevant copper/zinc complex are still unknown. Here we report on the isolation of these two species, their spectroscopic characterization, and the determination of their structure by single‐crystal X‐ray diffraction. First orienting experiments on the stability of the cuprate reagent in solution at room temperature as well as its reactivity towards allyl bromides were subsequently performed.