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Synthesis, Physicochemical Characterization, and Cytotoxicity Assessment of CeO 2 Nanoparticles with Different Morphologies
Author(s) -
Spezzati Giulia,
Fant Kristina,
Ahniyaz Anwar,
LundinJohnson Maria,
Hensen Emiel J. M.,
Langermans Harm,
Hofmann Jan P.
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201700248
Subject(s) - nanoparticle , chemistry , cytotoxicity , nanomaterials , nanotechnology , characterization (materials science) , physisorption , surface charge , pyrolysis , chemical engineering , hydrothermal circulation , nanometre , nuclear chemistry , materials science , organic chemistry , in vitro , biochemistry , adsorption , engineering
With the growing use of nanomaterials, it is essential to carefully determine whether they represent a risk for potential users. So far, validated stand‐alone methods that allow a proper risk assessment are still rare. In the present study, the cytotoxicity of CeO 2 nanoparticles has been assessed. For this purpose, a variety of well‐defined CeO 2 nanoparticles has been prepared by using either hydrothermal synthesis or flame spray pyrolysis (FSP), resulting in nanoparticles of different morphologies and sizes. The FSP technique is known to produce particles of a very small size (in the range of nanometers), which can easily become airborne. We employed a characterization procedure that makes use of physicochemical techniques, comprising N 2 physisorption, XRD, TEM, as well as ζ ‐potential and surface‐charge measurements. The cytotoxicity of the nanoparticles was evaluated in vitro on two different human lung cell lines (A549 and MRC‐5). The tests showed that, despite the differences in surface properties, size, and morphologies, neither of the CeO 2 samples gave rise to a cytotoxic response.