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Pt and Ti Complexes Immobilized onto Mesoporous Silica Microspheres and Their Interaction with Molecules of Biological Interest
Author(s) -
del Hierro Isabel,
Pérez Yolanda,
Cruz Paula,
Juárez Rafael
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201700235
Subject(s) - chemistry , propargyl alcohol , mesoporous material , mesoporous silica , click chemistry , platinum , titanium , alkyne , adsorption , molecule , combinatorial chemistry , polymer chemistry , nuclear chemistry , chemical engineering , organic chemistry , catalysis , engineering
Mesoporous silica microspheres (MSMs) have been functionalized with triazole and pendant hydroxy moieties by a postsynthetic procedure. The functionalities have been prepared by a very efficient azide/alkyne click reaction with propargyl alcohol to yield the corresponding 1,2,3‐triazole. The subsequent reaction with cisplatin and titanocene as metallic precursors produces platinum and titanium complexes tethered onto the silica surface. The synthesized materials have been fully characterized by dynamic recrystallization kinetics (DRX), FTIR, N 2 adsorption/desorption techniques, TEM, diffuse reflectance (DR) UV/Vis and 13 C cross polarization/magic angle spinning (CP/MAS) NMR spectroscopy. In addition, the interaction of these materials with molecules of biological interest such as guanosine and bovine serum albumin has been studied by means of solid‐state voltammetry techniques. Drug‐release experiments in simulated body fluid show sustained release profiles for the platinum complexes.