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A Straightforward Synthesis of 1,2‐Azaphosphindoles
Author(s) -
Zhang Lujun,
Liu Changchun,
Duan Zheng,
Mathey François
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201700209
Subject(s) - chemistry , protonation , lithium (medication) , bromide , medicinal chemistry , benzyl bromide , organic chemistry , combinatorial chemistry , ion , catalysis , medicine , endocrinology
Treatment of ortho ‐(diphenylphosphanyl)phenyl nitriles with an excess of lithium at room temperature in THF gives 1,2‐azaphosphindolides, which can react with RX (benzyl bromide, 1‐bromopropane, and 1,2‐dibromoethane) to form 2 H ‐1,2‐azaphosphindoles and give the aromatic 1 H ‐1,2‐azaphosphindoles upon protonation.
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