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Multivalent Azide‐Functionalized Polypyridyl Ruthenium Complexes and Their DNA Conjugates through Click Chemistry
Author(s) -
Sartor Valerie,
Irvoas Joris,
Bordeau Guillaume,
ChouiniLalanne Nadia
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201700174
Subject(s) - ruthenium , chemistry , azide , click chemistry , alkyne , cycloaddition , combinatorial chemistry , oligonucleotide , conjugate , dna , polymer chemistry , catalysis , organic chemistry , mathematical analysis , biochemistry , mathematics
A new series of azide‐functionalized ruthenium complexes were synthesized. Six trisbipyridine ruthenium complexes bearing one to six azide functions were developed from the corresponding carboxy derivatives. By using four alkyne‐functionalized DNA sequences and performing copper‐catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry reactions, the formation of symmetric and unsymmetric multivalent DNA–ruthenium conjugates was realized. They are composed of one to six oligonucleotides.