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Synthesis, Structure and Antitumoural Activity of Triazole‐Functionalised NHC–Metal Complexes
Author(s) -
Monticelli Marco,
BelleminLaponnaz Stéphane,
Tubaro Cristina,
Rancan Marzio
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201700142
Subject(s) - chemistry , carbene , moiety , ruthenium , ligand (biochemistry) , triazole , combinatorial chemistry , metal , aqueous solution , copper , click chemistry , stereochemistry , cancer cell lines , polymer chemistry , organic chemistry , cancer cell , receptor , catalysis , cancer , biochemistry , medicine
Silver(I), gold(I), copper(I) and ruthenium(II) N‐heterocyclic carbene (NHC) complexes have been synthesised and their cytotoxic activities towards various cancer cell lines have been evaluated. The N‐heterocyclic carbene ligand has been functionalised with a 1,2,3‐triazole moiety tethered in the backbone of the ligand. The molecular structure of the silver(I) and gold(I) complexes has been solved by X‐ray diffraction analysis. The Ag I , Au I and Ru II complexes display good stability in aqueous conditions and show cytotoxic activities comparable or slightly superior to those of similar unfunctionalised complexes.