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Synthesis, Characterization, Speciation, DNA Cleavage, and Cytotoxic Studies of the Pd[2‐(2‐Aminoethyl)‐1‐methylpyrrolidine]Cl 2 Complex with Reference to Carboplatin
Author(s) -
Shehata Mohamed R.,
Shoukry Mohamed M.,
Ragab Mona S.,
van Eldik Rudi
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201601524
Subject(s) - chemistry , stoichiometry , dna , ligand (biochemistry) , carboxylate , stereochemistry , crystallography , medicinal chemistry , biochemistry , receptor
The [Pd(AEMP)Cl 2 ] complex [AEMP = 2‐(2‐aminoethyl)‐1‐methylpyrrolidine] was prepared and characterized by single‐crystal X‐ray diffraction and spectroscopic analyses. The structure of the complex was found to be square‐planar with some distortion. The geometric optimizations of the ligand and complex were performed with the DFT/B3LYP method by using Gaussian 09. The stoichiometry and stability constants of the complexes formed in the reaction of [Pd(AEMP)(H 2 O) 2 ] 2+ with dicarboxylic acids and DNA constituents were investigated at 0.1 m ionic strength and 25 °C. The results show that both DNA constituents and cyclobutanedicarboxylate (CBDCA) coordinate to [Pd(AEMP)(H 2 O) 2 ] 2+ to form the quaternary complex [Pd(AEMP)(CBDCA‐O)DNA], where CBDCA‐O represents cyclobutanedicarboxylate coordinated through one carboxylate oxygen atom to the Pd II center. The speciation concentration distributions in solution were evaluated. The biological activity for DNA cleavage and cytotoxicity of the [Pd(AEMP)Cl 2 ] complex was studied.