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Iron(III) Pincer Complexes as a Strategy for Anticancer Studies
Author(s) -
EstradaMontaño Aldo S.,
Ryabov Alexander D.,
Gries Alexandre,
Gaiddon Christian,
Le Lagadec Ronan
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201601350
Subject(s) - chemistry , transmetalation , pincer movement , electron paramagnetic resonance , cyclic voltammetry , metathesis , cisplatin , medicinal chemistry , stereochemistry , nuclear chemistry , polymerization , nuclear magnetic resonance , organic chemistry , electrochemistry , catalysis , medicine , physics , polymer , surgery , electrode , chemotherapy
[Fe(NCN) 2 ]PF 6 ( 1· PF 6 ) [NCHN = 1,3‐di(pyridin‐2‐yl)benzene] was readily obtained by a transmetalation reaction between [Fe 3 (CO) 12 ] and Hg(NCN)Cl followed by a metathesis reaction with KPF 6 . X‐ray diffraction, electron paramagnetic resonance spectroscopy, and cyclic voltammetry studies confirmed the proposed structure. Cytotoxic assays in human colon cancer (HCT‐15), lung cancer (SKLU), and gastric cancer (AGS, KATOIII) cells were performed, and the IC 50 data obtained for all cell lines showed that 1· PF 6 has a much higher activity than cisplatin.