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Biological Evaluation of l ‐Tyrosine Labelled with fac ‐[ 99m Tc(CO) 3 ] + at a para ‐OH‐Coupled 2,3‐Diaminopropionic Acid Based Chelator
Author(s) -
Felber Michael,
Bauwens Matthias,
Imstepf Sebastian,
Fox Thomas,
Mottaghy Felix M.,
Alberto Roger
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201601316
Subject(s) - biodistribution , chemistry , in vivo , tyrosine , amino acid , radiochemistry , biochemistry , in vitro , microbiology and biotechnology , biology
Radiolabeled amino acids as metabolic tracers are increasingly important for imaging and therapy applications. There are only a few reports on 99m Tc‐labeled amino acids that have been evaluated in vivo. In this work we coupled a small and highly potent chelator for the fac ‐[ 99m Tc(CO) 3 ] + core to l ‐tyrosine through a poly(ethylene glycol) linker and investigated the in vivo biodistribution of the 99m Tc‐labeled l ‐tyrosine derivative. In vivo evaluation and biodistribution in mice bearing C6‐tumor xenografts revealed little tumor and pancreas uptake. The microSPECT images showed rapid clearance from the blood pool. Fast uptake into the gallbladder and an extended residence time makes this labeled tyrosine suitable for gallbladder imaging and associated dysfunctions.