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An Antibacterial Zn–MOF with Hydrazinebenzoate Linkers
Author(s) -
Restrepo Jimmy,
Serroukh Zakarias,
SantiagoMorales Javier,
Aguado Sonia,
GómezSal Pilar,
Mosquera Marta E. G.,
Rosal Roberto
Publication year - 2017
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201601185
Subject(s) - chemistry , linker , antimicrobial , staphylococcus aureus , ligand (biochemistry) , metal , metal organic framework , bacteria , combinatorial chemistry , zinc , bacterial growth , nuclear chemistry , organic chemistry , biochemistry , receptor , adsorption , biology , computer science , genetics , operating system
A Zn‐based metal–organic framework (MOF) with hydrazinebenzoate linkers was evaluated as antimicrobial material against the Gram‐positive bacterium Staphylococcus aureus . The material inhibits bacterial growth and metabolic activity, with a half maximal effective concentration of about 20 mg L –1 material dispersed in the culture medium. The antimicrobial effect can be attributed to the release of the 4‐hydrazinebenzoate linker, with a negligible contribution from the free metal. The material exhibits remarkable durability, and it enables the sustained release of the ligand over a period of several days.
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