Premium
Effect of Magnesium on the Solubility of Hydroxyapatite
Author(s) -
Liu Quan,
Chen Zhuofan,
Pan Haobo,
Darvell Brian W.,
Matinlinna Jukka Pekka
Publication year - 2016
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201601056
Subject(s) - magnesium , solubility , chemistry , crystallinity , inorganic chemistry , nucleation , magnesium deficiency (plants) , titration , nuclear chemistry , organic chemistry , crystallography
As an abundant cation in the human body, magnesium plays important roles in physiological and pathological processes. In particular, magnesium deficiency is associated with osteoporosis. Hence, Mg may be involved in the biodegradation and reconstruction of bone mineral. Previously, Mg‐containing hydroxyapatite (HAp) has been synthesized as a model for bone mineral, and its properties, such as crystal size and crystallinity, have been examined. However, the effect of solution magnesium on the effective solubility of hydroxyapatite has not been studied in detail. Here, for a series of magnesium concentrations in the background solution, the mass solubility of hydroxyapatite was determined through the solid titration method at pH 3–5 and 37 °C. A general, quasilogarithmic increase in solubility was found with increasing magnesium concentration. Whether this is due to nucleation inhibition or solution complexation has yet to be ascertained, although the latter is likely on simple chemical grounds. As the direct effect of magnesium was to increase the solubility of HAp in a concentration‐dependent manner, this cannot be the direct cause of osteoporosis in the event of magnesium deficiency.