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Progress in the Synthesis and Bioactivity of Hexacoordinate Silicon(IV) Complexes
Author(s) -
Henker Jens,
WirmerBartoschek Julia,
Bendel Lars Erik,
Xiang Yonggang,
Fu Chen,
Harms Klaus,
Schwalbe Harald,
Meggers Eric
Publication year - 2016
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201600953
Subject(s) - hexacoordinate , chemistry , silicon , ligand (biochemistry) , combinatorial chemistry , hydrolysis , stereochemistry , organic chemistry , biochemistry , receptor
(Arenediolato)bis(polypyridyl)silicon(IV) complexes contain hexacoordinate silicon and are surprisingly stable against hydrolysis in water. In an ongoing research program, we are aiming to exploit them as new structural templates for the design of bioactive compounds. As a follow‐up to previous work, here we present our progress in the synthesis of hexacoordinate silicon complexes by selective ortho ‐double nitration of the electron‐rich catecholato ligand, followed by reduction to diamines and condensation either with 1,2‐diketones or with aldehydes. Binding epitopes of some representative complexes to G‐quadruplex DNA as determined by NMR spectroscopic titration are presented.