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Cytotoxic Effects of Co 1– x Mn x Fe 2 O 4 Ferrite Nanoparticles Synthesized under Non‐Hydrolytic Conditions (Bradley's Reaction) – In Vitro
Author(s) -
Zachanowicz Emilia,
Zięcina Aleksander,
Mikołajczyk Paulina A.,
Rogacki Krzysztof,
Małecka Małgorzata,
Marycz Krzysztof,
Marędziak Monika,
Poźniak Błazej,
Nowakowska Marta,
Tikhomirov Marta,
Miller Julia,
Wiglusz Rafał J.,
Pązik Robert
Publication year - 2016
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201600720
Subject(s) - chemistry , nanoparticle , dynamic light scattering , cytotoxic t cell , bovine serum albumin , cell culture , crystallite , nuclear chemistry , crystallography , chemical engineering , nanotechnology , chromatography , biochemistry , materials science , biology , engineering , genetics , in vitro
Co 1– x Mn x Fe 2 O 4 ferrite nanoparticles have been synthesized by employing a microwave‐stimulated technique under non‐hydrolytic conditions. Structural, chemical, and morphological characterizations were carried out by XRD, SEM‐EDS, and TEM techniques. The stability of the nanoparticles and their tendency to form agglomerates were investigated by dynamic light scattering, exploiting the effect of different biological environments and protein stabilization. It was shown that bovine serum albumin adsorption was dependent upon the concentration and chemical composition of the nanaoparticle, showing higher affinities with increasing Co 2+ content. The cytotoxicities of the nonsurface‐blocked Co 1– x Mn x Fe 2 O 4 nanoparticles were assessed for three cell lines: phagocytic murine macrophage (J774.E), cancer fibroblast human osteosarcoma (HTB), and mesenchymal stem cells derived from human adipose tissue (ASCs). The results indicate that the cytotoxic response strongly depends on the particle concentration as well as the type of cell line.