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A Promising Catalytic and Theranostic Agent Obtained through the In‐Situ Synthesis of Au Nanoparticles with a Reduced Polyoxometalate Incorporated within Mesoporous MIL‐101
Author(s) -
RochMarchal Catherine,
Hidalgo Tania,
Banh Hung,
Fischer Roland A.,
Horcajada Patricia
Publication year - 2016
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201600359
Subject(s) - polyoxometalate , mesoporous material , chemistry , nanoparticle , catalysis , in situ , chemical engineering , composite number , nanotechnology , porosity , materials science , organic chemistry , composite material , engineering
A well‐controlled three‐step green synthetic method allows the synthesis of composite materials based on the highly stable chromium(III) terephthalate MIL‐101(Cr) with gold nanoparticles (NPs) and polyoxometalates (POMs) inside its mesopores. First, the POM was included within the MIL‐101(Cr) cavities through the direct synthesis of MIL‐101(Cr) in the presence of the preformed H 3 PMo 12 O 40 POM. Then, the incorporated POM was reduced in situ with H 2 . Finally, an in‐situ soft reduction of HAuCl 4 by the reduced POM led to the formation of Au NPs and oxidized POM within the MIL‐101(Cr) structure [(Au)H 2red POM@101]. A final Au/POM atomic ratio of 1.8 was reached. The chemical and structural stabilities of both MIL‐101(Cr) and the POM were preserved during the whole process. In addition to the potential catalytic properties of these highly porous composite systems, we have demonstrated their promising performance as optical contrast agents. The (Au)H 2red POM@101 composites exhibited excellent biostability and were rapidly internalized in macrophage cells, as observed through fluorescence confocal microscopy.