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In vitro Cytotoxicity of Half‐Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand
Author(s) -
Burgoyne Andrew R.,
Kaschula Catherine H.,
Parker M. Iqbal,
Smith Gregory S.
Publication year - 2016
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201501458
Subject(s) - chemistry , iridium , cationic polymerization , denticity , cytotoxicity , ligand (biochemistry) , alkylation , proton nmr , stereochemistry , nuclear magnetic resonance spectroscopy , metal , medicinal chemistry , in vitro , organic chemistry , biochemistry , catalysis , receptor
Trinuclear and model mononuclear cationic monodentate Rh III , Ir III and Ru II complexes with alkylated 1,3,5‐triaza‐7‐phosphaadamantane (PTA) moieties have been prepared and characterized using NMR and IR spectroscopy, HR‐ESI mass spectrometry and elemental analysis. The metals coordinate to the ligands via the phosphorus of the PTA, and this was confirmed by shifts in the 31 P{ 1 H} NMR spectra. The cytotoxicities of all the compounds were investigated against the WHCO1 esophageal cancer cell line. The Ir III mononuclear complex proved to be the most cytotoxic. Additionally, 1 H NMR model studies demonstrated its DNA binding ability while UV/Vis studies demonstrated the ability of the iridium mononuclear complex to interact with the double helix structure of Red Salmon testes DNA.