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Macrocyclic Platinum(II) Complexes with a Bifunctional Diphosphine Ligand
Author(s) -
Pascui Andrea E.,
van Rees Karlotta,
Zant Dirk W.,
Broere Daniël L. J.,
Siegler Maxime A.,
van der Vlugt Jarl Ivar
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201501055
Subject(s) - chemistry , bifunctional , ligand (biochemistry) , isomerization , benzaldehyde , amination , medicinal chemistry , platinum , reductive amination , coordination complex , stereochemistry , diamine , polymer chemistry , organic chemistry , catalysis , biochemistry , receptor , metal
The preparation and coordination chemistry of a ditopic ligand scaffold ( 1 H2 ), containing both a phosphorus‐donor ( P ) and a nitrogen‐donor ( N ) binding pocket, is reported. The ligand was synthesized by reductive amination from 3‐(diphenylphosphino)benzaldehyde and N ‐(2‐aminophenyl)‐ N ‐methylbenzene‐1,2‐diamine. Selective coordination in the P ‐pocket was achieved for Pt II , with careful control over the reaction conditions and precursor materials providing access to either the thermodynamic cis isomer, cis ‐PtCl 2 ( 1 H2 ) ( 2 ), or the kinetic trans isomer, trans ‐PtCl 2 ( 1 H2 ) ( 3 ). Both species have been fully characterized both in the solid state and in solution. Thermodynamic parameters for isomerization processes of 2 and 3 have been determined. Halide abstraction from 2 and 3 led to formation of cis ‐[Pt(CH 3 CN)(Cl)( 1 H2 )]BF 4 and trans ‐[Pt(CH 3 CN)(Cl)( 1 H2 )]BF 4 .