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Artificial Diiron Enzymes with a De Novo Designed Four‐Helix Bundle Structure
Author(s) -
Chino Marco,
Maglio Ornella,
Nastri Flavia,
Pavone Vincenzo,
DeGrado William F.,
Lombardi Angela
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201500745
Subject(s) - chemistry , helix bundle , cover (algebra) , bundle , helix (gastropod) , enzyme , stereochemistry , scaffold protein , crystallography , nanotechnology , protein structure , biochemistry , engineering , mechanical engineering , ecology , signal transduction , materials science , snail , composite material , biology
Invited for the cover of this issue is the group of Angela Lombardi at the University of Napoli “Federico II”, Italy. The cover image shows a construction site where workers are building up a four‐helix bundle scaffold. Fine‐tuning of the metal binding site, which is the heart of the construction, enables a specific function, such as oxidative chemistry. This approach has been successfully employed to develop diiron–oxo protein models.