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Synthesis of CaTiO 3 Nanofibers with Controllable Drug‐Release Kinetics
Author(s) -
Zhang Qiuhong,
Li Xiang,
Ren Zhaohui,
Han Gaorong,
Mao Chuanbin
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201500737
Subject(s) - nanofiber , electrospinning , chemistry , chemical engineering , kinetics , calcium titanate , drug delivery , pulmonary surfactant , ibuprofen , fiber , nanotechnology , materials science , organic chemistry , polymer , ceramic , biochemistry , medicine , physics , quantum mechanics , engineering , pharmacology
Calcium titanate (CaTiO 3 ) nanofibers with controlled microstructure were fabricated by a combination of sol–gel and electrospinning approaches. The fiber morphology has been found to rely significantly on the precursor composition. Altering the volume ratio of ethanol to acetic acid from 3.5 to 1.25 enables the morphology of the CaTiO 3 nanofibers to be transformed from fibers with a circular cross section to curved ribbon‐like structures. Ibuprofen (IBU) was used as a model drug to investigate the drug‐loading capacity and drug‐release profile of the nanofibers. It was found that the BET surface area and the pore volume decrease markedly with the utilization of F127 surfactant. The nanofibers synthesized without F127 surfactant present the highest drug‐loading capacity and the most sustained release kinetics. This study suggests that calcium titanate nanofibers can offer a promising platform for localized drug delivery.