Premium
Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu II Complexes with Bidentate N‐Heteroaromatic Schiff Base Ligands
Author(s) -
Todorović Tamara,
Grubišić Sonja,
Pregelj Matej,
Jagodič Marko,
MisirlićDenčić Sonja,
Dulović Marija,
Marković Ivanka,
Klisurić Olivera,
Malešević Aleksandar,
Mitić Dragana,
Anđelković Katarina,
Filipović Nenad
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201500349
Subject(s) - chemistry , tetracoordinate , electron paramagnetic resonance , denticity , crystallography , schiff base , dimer , ligand (biochemistry) , copper , pyridine , crystal structure , stereochemistry , medicinal chemistry , nuclear magnetic resonance , organic chemistry , receptor , computer science , planar , biochemistry , physics , computer graphics (images)
Copper(II) complexes with the condensation derivative of methyl hydrazinoacetate and 2‐acetylpyridine were synthesized. The X‐ray crystal structures for both complexes revealed that they are polymerized isomers. A common feature of both complexes is the bidentate coordination of the ligand by one hydrazone and one pyridine nitrogen atom. In the monomeric complex, the copper(II) center is tetracoordinate, whereas dimerization through chlorido bridges results in a pentacoordinate arrangement about the metal ions in the dimer. The electronic and magnetic properties of both complexes are discussed on the basis of their X‐ray structures, electron paramagnetic resonance (EPR) spectroscopy studies, and superconducting quantum interference device (SQUID) magnetization measurements combined with DFT calculations. Magnetostructural comparisons with structurally similar copper(II) complexes are also provided, and a possible correlation has been established. The antitumor activities of the Cu II complexes were investigated against six different cancer cell lines, and the results suggest that the antiglioma action of the dimeric species is based on oxidative‐stress‐mediated phosphatidylserine externalization and caspase activation, which indicate apoptosis.