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Magnetofluorescent Nanoaggregates Incorporating Terbium(III) Complexes as Potential Bimodal Agents for Magnetic Resonance and Optical Imaging
Author(s) -
Harris Michael,
Carron Sophie,
Vander Elst Luce,
Laurent Sophie,
ParacVogt Tatja.
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201500310
Subject(s) - terbium , chemistry , magnetic moment , relaxation (psychology) , europium , ion , nuclear magnetic resonance , excitation , rotational correlation time , gadolinium , lanthanide , ligand (biochemistry) , molecule , condensed matter physics , social psychology , psychology , biochemistry , physics , receptor , organic chemistry , engineering , electrical engineering
Terbium(III) ions were coordinated to two diethylenetriaminepentaacetic acid (DTPA) amphiphilic bisamide ligands, and the complexes were assembled into micellar nanoaggregates. The magnetic and optical properties of the resulting nanoaggregates were examined in detail. Upon excitation into the ligand levels at 265 nm, the complexes show characteristic Tb III emission at 546 nm with quantum yields of up to 7.6 %. Nuclear magnetic relaxation dispersion (NMRD) measurements have shown that the transverse relaxivity r 2 at 500 MHz and 310 K reaches a maximum value of 9.4 s –1 m M –1 . The efficient T 2 relaxivity at high magnetic field strengths is sustained by the increased rotational correlation time of the nanoaggregates and high magnetic moment of the terbium ion.