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Uniform Poly(acrylic acid)‐Functionalized Lanthanide‐Doped LaVO 4 Nanophosphors with High Colloidal Stability and Biocompatibility
Author(s) -
Nuñez Nuria O.,
Zambrano Paola,
GarcíaSevillano Jorge,
Cantelar Eugenio,
RiveraFernández Sara,
de la Fuente Jesús M.,
Ocaña Manuel
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201500265
Subject(s) - lanthanide , chemistry , nanoparticle , biocompatibility , acrylic acid , ethylene glycol , nanomaterials , colloid , nuclear chemistry , precipitation , doping , chemical engineering , vanadate , inorganic chemistry , nanotechnology , polymer chemistry , materials science , polymer , organic chemistry , ion , copolymer , physics , meteorology , engineering , optoelectronics
Ln‐doped (Ln = Eu or Nd) LaVO 4 nanoparticles functionalized with poly(acrylic acid) (PAA) were prepared from lanthanide and vanadate precursors in the presence of PAA by a simple one‐pot method that consists of a homogeneous precipitation reaction in ethylene glycol/water at a moderate temperature (120 °C). The size of the nanoparticles could be modified in the 40–70 nm range by adjusting the amount of PAA added. The effects of the Eu and Nd contents of these nanomaterials on theirs optical properties (emission intensity and lifetime) were also analyzed to find the optimum nanophosphors. Finally, the nanoparticles showed negligible cytotoxicity for Vero cells at concentrations up to 0.05 mg mL –1 and a high colloidal stability in physiological buffer solutions; therefore, they satisfy the most important requirements for in vitro biotechnological applications.