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A Chemoselective and Modular Post‐Synthetic Multi‐Functionalization of NHC–Platinum Complexes
Author(s) -
Dahm Georges,
Borré Etienne,
Guichard Gilles,
BelleminLaponnaz Stéphane
Publication year - 2015
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201500116
Subject(s) - chemistry , bioconjugation , surface modification , combinatorial chemistry , ligand (biochemistry) , oxime , platinum , organic chemistry , catalysis , biochemistry , receptor
Abstract We report oxime ligation in combination with metal ligand exchange as a novel orthogonal and practical approach to the multifunctionalization of NHC–platinum complexes. This strategy, which enables strong diversity enhancement of metallodrug candidates, could also be applied to selective bioconjugation.